GloucesterTimes.com, Gloucester, MA

May 21, 2007

Hepatitis C and its long-term effects are a growing problem

By Health Beat , Elizabeth Eddy

In the next decade, several million baby boomers will face the serious, long-term effects of the liver disease hepatitis C.

Three to four million people in the United States and an estimated 100,000 in Massachusetts have chronic hepatitis C, compared to 1 million who have HIV.

"(It's) a huge, huge problem worldwide," says Dr. Lucas Wolf, an infectious disease specialist who practices in Gloucester. "It's quickly becoming an extremely important disease in the U.S."

Wolf added that many baby boomers will be diagnosed with cirrhosis (fibrosis or scarring of the liver that prevents it from functioning properly) in the next 10 years, making hepatitis C a public-health threat.

Hepatitis C differs from the other types of hepatitis because nine out of 10 people who get it go on to suffer chronic infection. But unlike hepatitis A and B, there is no preventive vaccine for hepatitis C.

Hepatitis C also differs from the other types because there is virtually no acute phase. Often, it's only detected through routine liver function tests.

"It establishes itself with minimal or no symptoms other than some fatigue and abdominal pain," Wolf said. "People find out through an unexpected route as opposed to being symptomatic. Most of the 4 million infected don't know they have it."

The primary cause of hepatitis C is the sharing of infected needles, Wolf said. Blood-to-blood contact is required, he said, adding that the sharing of needles from heroin use is the most common route of transmission.

But while 80 percent of cases are due to intravenous drug use, there is a smattering of other transmission routes, including infection from nasally inhaled cocaine, tattoos made with dirty needles and blood transfusions before 1992.

Wolf encourages anyone who has ever shared a needle or who was a regular cocaine user to be tested.

"I generally see patients that are boomers and experimented with heroin once or twice in the late 1970s or 1980s," he said.

The North Shore Health Project in Gloucester focuses on hepatitis C and HIV services and offers testing, counseling and holistic health treatments such as acupuncture, massage, Reiki, energy healing, chiropractic care and yoga.

The group also provides case management and advocacy, assists clients with choosing medical care and offers congregate meals, educational programs and a drop-in center to support those facing hepatitis C. All services are free.



"We try to focus holistically on those undergoing interferon (immune stimulant) treatment because it is difficult," said executive director Susan Oleksiw. "We work with the whole person and advocate for stable housing and stable life situations, because dealing with hep C is a major life issue. When it hits you, it hits you hard."

Wolf added, "Hep C is extremely variable from person to person and hard to predict. You can live 20 to 30 years without symptoms, but in general, people are going to get to the point of cirrhosis in 30 to 40 years. The virus gets into the blood and sets up shop in the liver, and though it stays under the radar in the immune system, the liver becomes chronically inflamed and scarring accumulates over the fullness of time."

Treatment is determined after a liver biopsy, a minor procedure performed under anesthesia. Most patients are treated with a combination of interferon and the medication Ribavirin, which weakens the virus. Patients are advised to be vaccinated against hepatitis A and B, two other viruses that attack the liver.

"There is more treatment in the works," Wolf said, adding he is hopeful better treatments will be available in the future.

The current treatment regime is successful in about 60 percent of cases, but it is long and intensive, requiring a full year. And because the drug therapy is toxic to the body, there are significant side effects, including depression.

The North Shore Health Project helps newly diagnosed persons chart a course of action to ensure the best medical treatment and social support. Its office at 67 Middle St. is open Monday through Friday from 9 a.m. to 5 p.m. For more, call the project at 978-283-0101 or Sunny Robinson, Gloucester public health nurse, at 281-9971. Vaccinations against hepatitis A and B for people with hepatitis C are available for free through the Health Department.

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This article, part of a regular health education series provided by the Gloucester Health Department and Addison Gilbert Hospital, is offered in recognition of May as Hepatitis Awareness Month.