Mon, Nov 23 2009

Published: October 13, 2007 09:44 am    PrintThis  

My view: Research lacking in link between cancer and oral contraceptives

By Susan Wadia-Ells
Gloucester Daily Times

October is National Breast Cancer Awareness Month, a good time to focus on the actual, probable and possible multiple causes behind this U.S. epidemic.

Given the recent uproar about the increased cost of contraceptive pills on college campuses, it makes sense to first look at possible links between "the Pill" and the rising rate of breast cancer in younger women in the U.S..

Fact No. 1: From 1979 to 1999, the rate of breast cancer for white women under 50, increased by 9.8 percent; the rate increase for young black women, was even higher, at 26.4 percent.

Fact No. 2: At year-end 2003, the rate of breast cancer in older or post-menopausal women dropped a huge and historic 14.7 percent after 90 million American women stopped filling their HRT (hormone replacement therapy) prescriptions in 2002, when the National Women's Health Initiative Study reported increased risks of developing breast cancer from using HRT.

Since HRT and the Pill both do their work by adding hormones to the body, it is therefore important to also look at possible links between breast cancer and current oral contraceptive drugs.

A team of researchers, headed by Chris Kahlenborn, a family practitioner in Harrisburg, Penn., recently completed a statistical compilation of all published research, examining possible links between the older generation of oral contraceptives and breast cancer in women less than 50 years old. The numbers were not good.

Published in the October 2006 Mayo Clinic Proceedings, Dr. Kahlenborn found that women under 50, using the older generation of oral contraceptives, had a 44 percent increased risk of developing breast cancer over women who did not use the Pill.

This risk was even greater for women who used the Pill for at least four years prior to their first, full-term pregnancy. This group of mothers showed a 52 percent increased risk of developing breast cancer. A single study, conducted in Norway and Sweden in 1989, showed that long-time and current users of the Pill, who were currently under 45, had a 144 percent risk of developing breast cancer, compared with similar women who had never used the Pill.

Unfortunately, the American Cancer Society, the National Cancer Institute, Komen for the Cure, Avon Foundation and others have yet to fund research or publish studies that look at possible links between Nuva Ring, Ortho Tri-Cyclen Lo, other generic and brand-name oral contraceptive drugs and pre-menopausal women who are diagnosed with breast cancer each year.



When is the last time your physician mentioned that women currently using oral contraceptives are flying blind because there are no published studies on how current birth-control drugs affect one's risk of developing breast cancer? In fact, drug company brochures all cite 1980-era studies when discussing breast cancer risks and current oral contraceptive drugs.

Why is no one publishing studies about the breast cancer risks within this $3-billion U.S. oral contraceptives market? We now have 12 million teenagers, as well as women under 50, using the Pill, many beginning at earlier ages and many remaining on these drugs for longer than ever.

While people may think of the American Cancer Society as a foremost supporter of research, in 2005 it reported spending less than 10 percent of its nearly billion-dollar budget on independent scientific studies, laments Devra Davis, in her new book, "The Secret History of the War on Cancer". Davis, director of the Center for Environmental Oncology at the University of Pittsburgh Cancer Institute, describes in colorful and painful detail, how the ACS, controlled by business interests since 1945, played a leading role in blocking research and overtly misleading the public until the 1970s on the carcinogenic effects of tobacco. Is the ACS now playing this same role with oral contraceptives?

Until we conduct and publish research that examines links between current oral contraceptives and our rising rate of breast cancer in women under 50, it might be good that the cost of the Pill just tripled on college campuses. In fact, all of a sudden, the IUD option is looking far better and safer.

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Susan Wadia-Ells of Manchester-by-the-Sea is director of the National Breast Cancer Prevention Project and creator of the 1,000 Women Losing 10,000 Pounds Campaign. She can be reached at www.nationalbreastcancerprevention.org

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